2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-148689A
    SPC4061 sodium
    SPC4061 an antisense nucleotide, sodium is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases.
    SPC4061 sodium
  • HY-148689C
    SPC4061 sodium scrambled negative control 98%
    SPC4061 sodium scrambled negative control is the sequence scrambled negative control of SPC4061 sodium.
    SPC4061 sodium scrambled negative control
  • HY-148689D
    FAM labled SPC4061 sodium 98%
    FAM labled SPC4061 sodiumis a FAM labled SPC4061 sodium.
    FAM labled SPC4061 sodium
  • HY-148689E
    Cy3 labled SPC4061 sodium 98%
    Cy3 labled SPC4061 sodium is a Cy3 labled SPC4061 sodium.
    Cy3 labled SPC4061 sodium
  • HY-14894S2
    Pragliflozin-13C6 2743031-48-1 98%
    Pragliflozin-13C6 (ASP1941-13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent.
    Pragliflozin-13C6
  • HY-148978R
    18:0,18:1 PS sodium (Standard) 321883-23-2
    Resorantel (Standard) is the analytical standard of Resorantel. This product is intended for research and analytical applications. 18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage.
    18:0,18:1 PS sodium (Standard)
  • HY-14928S1
    Lobeglitazone-d4 98%
    Lobeglitazone-d4 is deuterium labeled Lobeglitazone. Lobeglitazone is a new type of thiazolidinedione. Lobeglitazone can be used to prevent type 2 diabetes mellitus (T2DM).
    Lobeglitazone-d4
  • HY-150172A
    Inosine 5'-triphosphate lithium salt 3056945-75-3 98%
    Inosine-5'-triphosphate (ITP) lithium salt is a nucleotide analogue that acts on multiple G proteins. Inosine-5'-triphosphate lithium salt can bind to the α -subunit of G proteins and participate in G protein-mediated signal transduction as a substitute for GTP. Inosine-5'-triphosphate lithium salt interacts with the nucleotide-binding site of the G protein α -subunit, affecting the activity and function of G proteins. Inosine-5'-triphosphate lithium salt is used to explore the role of the G protein signaling pathway in cellular physiological and pathological processes.
    Inosine 5'-triphosphate lithium salt
  • HY-150364C
    FAM labled Farabursen sodium 98%
    FAM labled Farabursen sodiumis a FAM labled Farabursen sodium.
    FAM labled Farabursen sodium
  • HY-150364D
    Cy3 labled Farabursen sodium 98%
    Cy3 labled Farabursen sodium is a Cy3 labled Farabursen sodium.
    Cy3 labled Farabursen sodium
  • HY-150521R
    Hispolon (Standard) 173933-40-9
    4-Hydrazinobenzoic acid (Standard) is the analytical standard of 4-Hydrazinobenzoic acid. This product is intended for research and analytical applications. 4-Hydrazinobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Hispolon (Standard)
  • HY-151500C
    JBSNF-000028 98%
    JBSNF-00002 is an orally active small molecule inhibitor of the tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values for human, mouse and monkey sources of NNMT of 33, 210 and 190 nM respectively. JBSNF-00002 can reduce endogenous MNA levels in U2OS osteosarcoma cells, with its EC50 being 2.5 μM. JBSNF-00002 exhibits significant anti-obesity and anti-diabetic activities in the diet-induced obesity (DIO) model. JBSNF-00002 can be used for the study of metabolic diseases such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.
    JBSNF-000028
  • HY-151591A
    SPAA-52 ammonium
    SPAA-52 (ammonium) is a low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50 = 4 nM; IC50 = 1.2 nM). SPAA-52 (ammonium) can be used in the research of diabetes mellitus.
    SPAA-52 ammonium
  • HY-151998S
    DMPG-d54 746595-58-4 98%
    DMPG-d54 is the deuterium labeled DMPG (1,2-Dimyristoyl-sn-glycero-3-phosphatidylglycerol). DMPG is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    DMPG-d54
  • HY-152008S
    Hexanoyl-L-carnitine-d3 hydrochloride 2692624-43-2 98%
    Hexanoyl-L-carnitine-d3 (hydrochloride) is deuterium labeled Hexanoyl-L-carnitine (chloride). Hexanoyl-L-carnitine (chloride) is an ester product.
    Hexanoyl-L-carnitine-d3 hydrochloride
  • HY-152017S
    C18 Globotriaosylceramide-d3 2692623-80-4 98%
    C18 Globotriaosylceramide-d3 is deuterium labeled Gb3(18:1/18:0). Gb3(18:1/18:0) (C18 Globotriaosylceramide (d18:1/18:0)) is an ester product.
    C18 Globotriaosylceramide-d3
  • HY-152775A
    RK-0133114 98%
    RK-0133114 is a G9a inhibitor and a R-enantiomer of RK-701 (HY-152775). RK-0133114 inhibits G9a with an IC50 value of 3.7 μM. RK-0133114 can be used for the research of sickle cell disease (SCD).
    RK-0133114
  • HY-153095A
    PF-6870961 hydrochloride 2857112-07-1 98%
    PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
    PF-6870961 hydrochloride
  • HY-153497C
    Vupanorsen sodium scrambled negative control 98%
    Vupanorsen sodium scrambled negative control is the sequence scrambled negative control of Vupanorsen sodium.
    Vupanorsen sodium scrambled negative control
  • HY-153497D
    FAM labled Vupanorsen sodium 98%
    FAM labled Vupanorsen sodiumis a FAM labled Vupanorsen sodium.
    FAM labled Vupanorsen sodium
Cat. No. Product Name / Synonyms Application Reactivity